Design and Construction of Class 100 Cleanroom Partition Walls Between Clean and General Area

Introduction

In pharmaceutical, semiconductor, and biotechnology facilities, maintaining strict separation between clean and general areas is critical. The partition wall system between Class 100 clean zones and general areas must ensure airtight integrity, contamination control, and structural stability. This article explores the detailed design and construction of such partition walls based on industry best practices.

1. Core Wall Structure

1.1 Wall Panel Composition

Layer	Material Specification	Key Properties
Outer Surface	1.2mm SUS316L stainless steel	Electro-polished (Ra ≤0.5μm), anti-microbial
Core	50mm fire-rated mineral wool	Non-combustible (A1 grade), sound insulation ≥45dB
Inner Surface	0.8mm pre-coated aluminum (PVDF finish)	Anti-static (10⁴–10⁶Ω), easy to clean

1.2 Framework System

Vertical Studs: 80×40×2mm aluminum alloy (anodized, ≤0.2mm/m tolerance)

Horizontal Rails: 50×30×1.5mm thermal-break profiles (spaced ≤600mm)

Seismic Joints: Stainless steel flexible couplings (±6mm movement capacity)

2. Critical Design Features

2.1 Airtight Sealing System

Primary Seal: EPDM gasket (compressed 25–30%) at panel joints

Secondary Seal: Non-sag silicone sealant (ASTM C920, 300% elongation)

Tertiary Seal: Pressure-equalized baffle system behind panels

2.2 Floor-to-Ceiling Integration

Base Detail:

100mm high stainless steel curb (integrated with epoxy flooring)

Continuous silicone fillet seal (45° chamfer)

Ceiling Interface:

Double-gasketed aluminum transition profile

HEPA-filtered air curtain at ceiling plenum

3. Construction Best Practices

3.1 Clean Assembly Protocol

Material Handling:

Wipe all components with IPA (Isopropyl Alcohol) before installation

Use dedicated cleanroom tools (e.g., HEPA-filtered vacuums)

Installation Sequence:

Install framework → Mount panels → Apply seals → Final pressure testing

3.2 Quality Control Tests

Test	Standard	Acceptance Criteria
Air Leakage	ISO 14644-7	≤0.1% leakage @250Pa differential
Surface Cleanliness	ISO 14644-8	≤5 particles (≥0.5μm)/m²
Static Dissipation	ANSI/ESD S20.20	Surface resistance 10⁵–10⁹Ω

4. Maintenance and Compliance

4.1 Routine Checks

Weekly: Inspect seal integrity (visual + smoke pencil test)

Monthly: Verify airflow patterns (≥0.45m/s at doorways)

4.2 Regulatory Alignment

Complies with:

GMP Annex 1 (Grade A/B to D transitions)

IEST-RP-CC012.6 (Cleanroom design)

NFPA 90A (Fire-rated barriers)

Conclusion

This partition wall system achieves zero cross-contamination through multi-tiered sealing, robust materials, and precision construction. For optimal performance:

Conduct BIM clash detection before installation

Perform as-built particle testing post-construction

Train staff on proper cleaning protocols

Need CAD details or material specifications? Contact our engineering team for customized solutions.

Key Takeaways:✔ Triple-sealed barrier with pressure differential control✔ Seamless integration with floor/ceiling systems✔ Full compliance with GMP/ISO cleanroom standards

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