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Installation Locations of Pass Boxes in Medical Research Laboratories
Created on 2025.12.26
In medical research laboratories, the safe transfer of samples, reagents, and materials is a critical aspect of operational compliance and biosafety control. Compared with frequent personnel movement, pass boxes provide a highly efficient, safe, and controllable method for material transfer. Correctly determining the installation location of a pass box is essential for maintaining laboratory cleanliness, stable pressure differentials, and minimizing cross-contamination risks.
I. Role of Pass Boxes in Medical Laboratories
Isolate contamination sources: Prevent air, dust, or microorganisms from entering clean areas
Protect core laboratory zones: Safeguard air quality in molecular biology, cell culture, or other high-cleanliness areas
Improve operational efficiency: Reduce personnel traffic and save time on gowning and disinfection
Standardize material flow: Ensure reproducible, controlled transfer procedures and reduce operational risks
II. Typical Installation Locations
Between clean and non-clean areas
Example: Sample receiving room → Core laboratory
Main function: Block direct air intrusion from non-clean areas
Usually equipped with dual-door interlock and optional UV sterilization to ensure safe transfer
Between areas of different cleanroom classifications
Example: ISO 8 buffer zone → ISO 7 core laboratory
Complies with the unidirectional flow principle, allowing materials to move only from lower to higher cleanliness zones
Requires interlock control, reverse-opening prevention, and clear labeling
Between functional process rooms
Example: Sample processing area → Molecular analysis area / Formulation area → Filling area
Installation should be adjacent to operation points to minimize secondary handling and improve workflow efficiency
Must consider equipment layout and personnel movement paths
III. Engineering Design Principles
Comply with cleanroom zoning and pressure differentials
Do not disrupt the planned airflow or pressure gradient
Follow material flow paths
Prioritize operational workflow and material movement efficiency
Avoid main personnel corridors
Ensure pass box placement does not interfere with routine laboratory operations
Facilitate cleaning and maintenance
Consider door swing, mounting height, and surrounding space for daily cleaning and maintenance access
IV. Conclusion
In medical research laboratories, pass boxes are more than material transfer devices—they are key nodes for biosafety and laboratory management. Proper installation ensures safe and efficient material flow, maintains cleanroom integrity, and provides a reliable environment for scientific research.
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