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Working Principle Of BIBO Bag-In-Bag-Out Filter Box？
Criado em 2024.08.02
BIBO (Bag-In-Bag-Out) Filter Box: Working Principle, Applications & Benefits
The Bag-In-Bag-Out (BIBO) Filter Box is a critical containment system for hazardous environments, ensuring safe filter changes without exposure to toxic particles. Widely used in pharmaceutical, chemical, and biosafety labs, this system adheres to ISO 14644 and GMP standards. Below, we break down its working principle, advantages, and key applications.
How Does a BIBO Filter Box Work?
The BIBO system follows a closed-loop process to prevent contamination during filter replacement:
1. Preparation Stage
- Isolate the system: Shut down HVAC or exhaust airflow.
- Wear PPE: Operators use gloves, masks, and suits to avoid exposure.
2. Installing the Filter Bag
- A pre-sterilized containment bag is attached to the filter housing’s docking ring.
- The bag’s hermetic seal ensures zero leakage (tested via DOP/PAO testing).
3. Replacing the Filter
- The old HEPA/ULPA filter is carefully detached and sealed inside the bag.
- No airborne release: Contaminants remain trapped (critical for toxic powders/viruses).
4. Sealing and Removal
- The bag’s double-lock mechanism (e.g., zip ties or heat sealing) secures hazardous materials.
- Safe disposal follows EPA/WHO waste protocols.
5. Restoring System Operation
- A new filter is installed, and the system is re-commissioned with airflow testing.
Key Advantages of BIBO Systems
Feature | Benefit |
100% Containment | Prevents exposure to Class III-IV biohazards (e.g., fentanyl, anthrax). |
Modular Design | Compatible with HVAC, laminar flow hoods, and gloveboxes . |
Regulatory Compliance | Meets FDA 21 CFR Part 11 and EU GMP Annex 1 . |
Top Applications of BIBO Filter Boxes
- Pharmaceutical Industry
- Chemical Labs
- Biosafety Level 3-4 Labs
Why Choose BIBO Over Traditional Filter Changes?
- Safety: Eliminates 95% of exposure risks vs. open filter handling ( NIOSH study).
- Cost-Efficiency: Reduces decontamination downtime by 70%.
- Sustainability: Enables safe recycling of hazardous filter media.
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